by https://www.mdpi.com/2218-273X/12/5/629/htm
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The data here shown are consistent with data presently published and features indicate that:
SARS-CoV-2 can directly infect the CNS even if it is not clear which is the direct type of brain tissue damage.
Morphological features indicate that SARS-CoV-2 related coagulation disorders are the main cause of the brain tissue damage. The immediate use of anticoagulant therapy in critical patients reduced thromboembolic complications.
Bacterial superinfection can be the cause of acute leptomeningitis during SARS-CoV-2 infection.
Brain damage can be present even in absence of specific neurological symptoms. Therefore, it is possible that brain involvement could be an underestimated feature in SARS-CoV-2 infected patients [48].
Astrogliosis, microglial activation and chronic inflammation could play a role for the development of chronic neurological disorders.”
